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Science 18 May 1973:
Vol. 180. no. 4087, pp. 757 - 758
DOI: 10.1126/science.180.4087.757
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Articles

Histamine: Effect on Self-Stimulation

Cal K. Cohn 1, Gordon G. Ball 1, and Jules Hirsch 1

1 Rockefeller University, New York 10021

When injected discretely into the lateral hypothalamus of rats, histamine inhibited electrical self-stimulation at the injection site without affecting self-stimulation in the contralateral lateral hypothalamus. This effect was blocked by prior treatment with antihistaminics. Histidine, the amino acid precursor of histamine, produced a similar effect after a delay of 6 to 10 minutes.


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Chorea and Cimetidine.
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Histaminergic Pathway in Rat Brain Evidenced by Lesions of the Medial Forebrain Bundle.
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