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Science 18 May 1973:
Vol. 180. no. 4087, pp. 741 - 743
DOI: 10.1126/science.180.4087.741
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Articles

Anticoagulant-Resistant Rats: Possible Control by the Use of the Chloro Analog of Vitamin K1

J. W. Suttie 1

1 Department of Biochemistry, College of Agricultural and Life Sciences, University of Wisconsin, Madison 53706

Strains of wild rats that are resistant to the anticoagulant action of coumarins and derivatives of indandione have been discovered in a number of geographic areas. These rats have now been shown to be more susceptible than normal rats are to the anticoagulant action of the vitamin K antagonist, 2-chloro-3-phytyl-1,4-naphthoquinone. This compound, either alone or in combination with warfarin, would appear to be an effective rodenticide in areas where resistance to the indirect anticoagulants is a problem.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)