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Science 11 May 1973:
Vol. 180. no. 4086, pp. 647 - 649
DOI: 10.1126/science.180.4086.647
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Articles

Pronase Effect on Pancreatic Beta Cell Secretion and Morphology

L. Orci 1, M. Amherdt 1, J. C. Henquin 2, A. E. Lambert 2, R. H. Unger 3, and A. E. Renold 3

1 Institute of Histology, University of Geneva, Geneva, Switzerland
2 Department of Internal Medicine, University Hospital, St. Pierre, Louvain, Belgium
3 Institute of Clinical Biochemistry, University of Geneva

Pronase at low concentration (4 micrograms per milliliter) produces a reversible increase of glucose-stimulated insulin release in isolated islets of Langerhans. Pronase also affects the ultrastructure of the beta cells by inducing extensive development of tight junctions as well as the accumulation of secretory product within the extracellular spaces.


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Exocrine pancreas: evidence for topographic partition of secretory function.
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