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Science 27 April 1973:
Vol. 180. no. 4084, pp. 408 - 410
DOI: 10.1126/science.180.4084.408
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Articles

Host Immunoglobulin G and Complement Deposits in the Choroid Plexus during Spontaneous Immune Complex Disease

Peter W. Lampert 1 and Michael B. A. Oldstone 1

1 Department of Experimental Pathology, Scripps Clinic and Research Foundation, and Department of Pathology, University of California, San Diego, La Jolla 92037

Hybrid (NZB x W)F1 mice spontaneously develop antibodies to nuclear antigens (ANA) and DNA (ADNA) and are an animal model of human systemic lupus erythematosus. Immunofluorescent and electron microscopic observations of the choroid plexus and renal glomeruli of (NZB x W)F1 mice reveal deposits of host immunoglobulin G (IgG) and the third complement component which appear shortly after the development of ANA and ADNA in the circulation. Additionally, enhancement of ADNA responses accelerates the appearance and severity of IgG deposits in the choroid plexus. The choroid plexus may be a favored site for the deposition of immune complexes and the neuropsychiatric findings in patients with systemic lupus erythematosus and some patients with acute or chronic infections may be related in part to immune complex disease of the choroid plexus.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Vascular Disease in Infective Endocarditis: Report of Immune-Mediated Events in Skin and Brain.
J. A. Davis, M. H. Weisman, and D. H. Dail (1978)
Arch Intern Med 138, 480-483
   Abstract »    PDF »
Lupus Erythematosus.
B. H. Hahn and L. V. Avioli (1975)
Arch Intern Med 135, 1617-1621
   Abstract »    PDF »
Brain Scan Findings in Central Nervous System Involvement by Lupus Erythematosus.
D. A. BENNAHUM, R. P. MESSNER, and J. D. SHOOP (1974)
Ann Intern Med 81, 763-765
   Abstract »    PDF »
The Choroid Plexus: Immunologic Injury and Disease.
R. M. MCINTOSH and M. M. KOSS (1974)
Ann Intern Med 81, 111-113
   Abstract »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)