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Science 27 April 1973:
Vol. 180. no. 4084, pp. 403 - 406
DOI: 10.1126/science.180.4084.403
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Articles

Cell Mediated Immunity: Separation of Cells Involved in Recognitive and Destructive Phases

Fritz H. Bach 1, Miriam Segall 1, Karen Stouber Zier 1, Paul M. Sondel 1, Barbara J. Alter 1, and Marilyn L. Bach 2

1 Department of Medical Genetics and Surgery, University of Wisconsin, Madison 53706
2 Departments of Pediatrics and Pharmacology, University of Wisconsin

The mixed leukocyte culture (MLC) and the cell mediated lympholysis (CML) assays are used as in vitro models of the afferent, or recognitive, and efferent, or destructive, phases of the homograft reaction. Activity in both of these tests has been related to differences at the major histocompatibility complex, HL-A in man and H-2 in mouse. Recent evidence suggests that the presumed cell surface differences which lead to cell proliferation in MLC are different from those which act as a target for CML. Data are presented providing further support for this hypothesis; in addition separate cell populations may respond to the differences which activate cells in MLC and to the differences which serve as targets for CML. There thus appears to be a dichotomy both for genetic control of, and cell populations involved in, the recognitive and destructive phases of cell mediated immunity.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Cellular Recognition of Major Histocompatibility Complex Antigens.
F. H. Bach, M. L. Bach, O. J. Kuperman, H. W. Sollinger, and P. M. Sondel (1977)
Cold Spring Harb Symp Quant Biol 41, 429-441
   Abstract »    PDF »
beta2-Microglobulin: Association with Lymphocyte Receptors.
M. L. Bach, S.-W. Huang, R. Hong, and M. D. Poulik (1973)
Science 182, 1350-1352
   Abstract »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)