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Science 20 April 1973:
Vol. 180. no. 4083, pp. 302 - 303
DOI: 10.1126/science.180.4083.302
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Articles

Hyaluronate Inhibition of Chondrogenesis: Antagonism of Thyroxine, Growth Hormone, and Calcitonin

Bryan P. Toole 1

1 Developmental Biology Laboratory, Departments of Medicine and Biological Chemistry, Harvard Medical School, and Massachusetts General Hospital, Boston 02114

The formation of cartilage-like aggregates in high-density stationary cultures of trypsinized chick embryo precartilage cells is blocked by low concentrations of hyaluronate. Thyroxine (and triiodothyronine), growth hormone, calcitonin, and adenosine 3',5'-monophosphate prevented this inhibition by hyaluronate, whereas other hormones tested did not.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Brain Hyaluronidase: Changes in Activity during Chick Development.
J. R. Polansky, B. P. Toole, and J. Gross (1974)
Science 183, 862-864
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Science. ISSN 0036-8075 (print), 1095-9203 (online)