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Science 20 April 1973:
Vol. 180. no. 4083, pp. 300 - 302
DOI: 10.1126/science.180.4083.300
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Articles

Intracellular Plutonium: Removal by Liposome-Encapsulated Chelating Agent

Yueh-Erh Rahman 1, Marcia W. Rosenthal 1, and Elizabeth A. Cerny 1

1 Division of Biological and Medical Research, Argonne National Laboratory, Argonne, Illinois 60439

Chelating agents, such as ethylenediaminetetraacetic acid (EDTA) and diethylenetriaminepentaacetic acid (DTPA) were successfully encapsulated within lipid spherules (that is, liposomes). Encapsutlated [14C]EDTA, given intravenously to mice, was retained longer in tissues that nonencapsulated [14C]EDTA. Encapsulated DTPA, given to mice 3 days after pluttonium injection, removed an additional fraction of plutonium in the liver, presumably intracellular, not available to nonencapslulated DTPA. It also further increased urinary excretion of plutonium. Introduction of chelating agents into cells by liposomal encapsulation is a promising new approach to the treatment of metal poisoning


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Liposome-cell interaction: transfer and intracellular release of a trapped fluorescent marker.
J. Weinstein, S Yoshikami, P Henkart, R Blumenthal, and W. Hagins (1977)
Science 195, 489-492
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