Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 13 April 1973:
Vol. 180. no. 4082, pp. 203 - 205
DOI: 10.1126/science.180.4082.203
Prev | Table of Contents | Next

Articles

Hepatitis B Virus Antigen: Validation and Immunologic Characterization of Low-Titer Serums with 125I-Antibody

C. M. Ling 1, H. Irace 1, R. Decker 1, and L. R. Overby 1

1 Department of Virology, Abbott Laboratories, North Chicago, Illinois 60064

Radioimmunnoassay was used to determine the serologic subspecificities of 85 blood donor serums positive for hepatitis B virus-associated antigen. There was complete agreement with results obtained by immunoprecipitatiotn of 43 serums. The remaining 42 serums were negative by immunoprecipitation but followed type-specific immunology by radioimmunoassay, and this served as a validation for authentic hepatitis B virus antigen.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Acute Viral Hepatitis in Adults: Comparison of the Radioimmunoassay and Counterimmunoelectrophoresis Methods of Detecting HBsAg.
R. P. Wenzel, C. D. Teates, Q. Galapon, R. Barczak, C.-m. Ling, and L. R. Overby (1975)
JAMA 232, 366-368
   Abstract »    PDF »
Nonspecificity of Hepatitis B Antigen Detected with Iodine-125-Labeled Antibody.
G. N. Vyas, S. G. Adelberg, H. A. Perkins, L. R. Overby, R. H. Decker, and C. M. Ling (1973)
Science 182, 1368-1371
   PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)