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Science 13 April 1973:
Vol. 180. no. 4082, pp. 203 - 205
DOI: 10.1126/science.180.4082.203
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Articles

Hepatitis B Virus Antigen: Validation and Immunologic Characterization of Low-Titer Serums with 125I-Antibody

C. M. Ling 1, H. Irace 1, R. Decker 1, and L. R. Overby 1

1 Department of Virology, Abbott Laboratories, North Chicago, Illinois 60064

Radioimmunnoassay was used to determine the serologic subspecificities of 85 blood donor serums positive for hepatitis B virus-associated antigen. There was complete agreement with results obtained by immunoprecipitatiotn of 43 serums. The remaining 42 serums were negative by immunoprecipitation but followed type-specific immunology by radioimmunoassay, and this served as a validation for authentic hepatitis B virus antigen.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Acute Viral Hepatitis in Adults: Comparison of the Radioimmunoassay and Counterimmunoelectrophoresis Methods of Detecting HBsAg.
R. P. Wenzel, C. D. Teates, Q. Galapon, R. Barczak, C.-m. Ling, and L. R. Overby (1975)
JAMA 232, 366-368
   Abstract »    PDF »
Nonspecificity of Hepatitis B Antigen Detected with Iodine-125-Labeled Antibody.
G. N. Vyas, S. G. Adelberg, H. A. Perkins, L. R. Overby, R. H. Decker, and C. M. Ling (1973)
Science 182, 1368-1371
   PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)