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Science 13 April 1973:
Vol. 180. no. 4082, pp. 193 - 195
DOI: 10.1126/science.180.4082.193
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Articles

Natural Abundance Carbon-13 Nuclear Magnetic Resonance Spectra of Human Serum Lipoproteins

James A. Hamilton 1, Charles Talkowski 1, Eliot Williams 1, Elba Marina Avila 1, Adam Allerhand 1, Eugene H. Cordes 1, and German Camejo 2

1 Department of Chemistry, Indiana University, Bloomington 47401
2 Instituto Venezolano de Investigaciones Científicas, Caracas, Venezuela

Human serum lipoproteins have been studied by Fourier transform nuclear magnetic resonance of carbon-13 in natural abundance. Spectra of highdensity, low-density, and very-low-density lipoproteins were recorded and partly assigned. The prominent features of these spectra reflect the qualitative and quantitative composition of the lipid moiety of these complexes. The results suggest that carbon-13 nuclear magnetic resonance will be a useful technique for studies of the structural and dynamic parameters of lipoproteins.


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