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Science 6 April 1973:
Vol. 180. no. 4081, pp. 79 - 81
DOI: 10.1126/science.180.4081.79
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Articles

Immunologic Manipulation of Metastases due to Herpesvirus Transformed Cells

Ronald Duff 1, Elizabeth Doller 1, and Fred Rapp 1

1 Department of Microbiology, Milton S. Hershey Medical Center, Pennsylvania State University, Hershey 17033

Herpes simplex virus type 1 (HSV-1), type 2 (HSV-2), and simian virus 40 (SV40) fail to induce immunity in weanling Syrian hamsters to transplant of hamster cells transformed by HSV-2. However, the development of metastatic tumors is markedly enhanced by prior immunization with HSV-1. Immunization with SV40, ultraviolet-irradiated tumor cells, or ultraviolet-irradiated normal hamster embryo cells inhibits the development of metastases. The HSV-hamster system appears a good one for the study of development, prevention, and control of metastases by mammalian cells transformed by a common human virus.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)