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Science 30 March 1973:
Vol. 179. no. 4080, pp. 1342 - 1343
DOI: 10.1126/science.179.4080.1342
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Articles

Insect Juvenile Hormones: Highly Potent Synthetic Mimics

Rafael Sarmiento 1, Terrence P. McGovern 1, Morton Beroza 1, G. D. Mills Jr. 2, and R. E. Redfern 2

1 Agricultural Environmental Quality Institute, Agricultural Research Center, U.S. Department of Agriculture, Beltsville, Maryland 20705
2 Plant Protection Institute, Agricultural Research Center, U.S. Department of Agriculture, Beltsville, Maryland 20705

The substitution of a 7-alkoxy group for the 6,7-epoxy moiety in aryl terpenoid ethers having high juvenile hormone activity has produced several compounds exceptionally active against Tenebrio molitor. The most potent compound [7-ethoxy-1-(p-ethylphenoxy)-3,7-dimethyl-2-octene, called JH-25] is active at the level of 10 picograms per insect, or about 100 times more active than other promising juvenile hormone mimics so far reported. Compound JH-25 was also active against Tribolium confusum.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)