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Science 30 March 1973:
Vol. 179. no. 4080, pp. 1330 - 1331
DOI: 10.1126/science.179.4080.1330
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Articles

Isolated Adrenal Cortex Cells: Hypersensitivity to Adrenocorticotropic Hormone after Hypophysectomy

George Sayers 1 and Robert J. Beall 1

1 Department of Physiology, School of Medicine, Case Western Reserve University, Cleveland, Ohio 44106

Cells from the adrenals of hypophysectomized rats (up to 28 days after operation) require less adrenocorticotropic hormone to induce one-half maximal rate of production of 3',5'-adenosine monophosphate than do cells from the adrenals of intact rats. A corresponding increase in sensitivity is reflected in the steroidogenic response to adrenocorticotropic hormone up to 2 days after hypophysectomy.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
The Pineal Gland: A Neurochemical Transducer.
J. Axelrod (1974)
Science 184, 1341-1348
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Science. ISSN 0036-8075 (print), 1095-9203 (online)