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Science 30 March 1973:
Vol. 179. no. 4080, pp. 1326 - 1328
DOI: 10.1126/science.179.4080.1326
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Articles

Electrogenic Sodium Pump in Squid Giant Axon

Paul De Weer 1 and Donald Geduldig 1

1 Department of Biophysics, University of Maryland School of Medicine, Baltimore 21201

Squid giant axon possesses a hyperpolarizing electrogenic sodium pump which is stimulated by internal sodium and by external potassium. This conclusion is based on the following observations: strophanthidin depolarizes the membrane and enhances the depolarizing effect of 5 or 10 millimolar external potassium; the magnitude of these effects is directly related to the internal sodium concentration; both effects are abolished by cyanide.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)