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Science 23 March 1973:
Vol. 179. no. 4079, pp. 1238 - 1240
DOI: 10.1126/science.179.4079.1238
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Articles

SV40 Virus Transformation of Mouse 3T3 Cells Does Not Specifically Enhance Sugar Transport

A. H. Romano 1 and C. Colby 1

1 Microbiology Section, University of Connecticut, Storrs 06268

The apparent enhancement of 2-deoxy-D-glucose uptake by mouse 3T3 cells accompanying transformation by SV40 virus is not due primarily to an effect on the transport process but to enhanced phosphorylation of the sugar by intracellular kinases. Moreover, the effect is not specifically a function of the presence of the viral genome, but is a reflection of the overall growth rate and physiological state of the cell.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)