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Science 23 March 1973:
Vol. 179. no. 4079, pp. 1235 - 1236
DOI: 10.1126/science.179.4079.1235
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Articles

Pyrethroid Insecticides: Esterase Cleavage in Relation to Selective Toxicity

Charles O. Abernathy 1 and John E. Casida 1

1 Division of Entomology and Parasitology, University of California, Berkeley 94720

The ester group of primary alcohol chrysanthemates is cleaved by mouse hepatic microsomal esterases, more rapidly for the (+)-trans than for the (+)-cis isomers. Substrate-specificity and inhibition studies in vivo establish that these pyrethroid-hydrolyzing esterases probably contribute to the low mammalian toxicity of bioresmethrin and other (+)-trans chrysanthemate insecticide chemicals derived from primary alcohols.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Identification of Rat and Human Cytochrome P450 Isoforms and a Rat Serum Esterase That Metabolize the Pyrethroid Insecticides Deltamethrin and Esfenvalerate.
S. J. Godin, J. A. Crow, E. J. Scollon, M. F. Hughes, M. J. DeVito, and M. K. Ross (2007)
Drug Metab. Dispos. 35, 1664-1671
   Abstract »    Full Text »    PDF »
Species Differences in the in Vitro Metabolism of Deltamethrin and Esfenvalerate: Differential Oxidative and Hydrolytic Metabolism by Humans and Rats.
S. J. Godin, E. J. Scollon, M. F. Hughes, P. M. Potter, M. J. DeVito, and M. K. Ross (2006)
Drug Metab. Dispos. 34, 1764-1771
   Abstract »    Full Text »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)