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Science 16 March 1973:
Vol. 179. no. 4078, pp. 1131 - 1133
DOI: 10.1126/science.179.4078.1131
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Articles

Cholesterol Hydroperoxide Formation in Red Cell Membranes and Photohemolysis in Erythropoietic Protoporphyria

A. A. Lamola 1, T. Yamane 1, and A. M. Trozzolo 1

1 Bell Laboratories, Murray Hill, New Jersey 07974

3beta-Hydroxy-5agr-hydroperoxy-Dgr6-cholestene is produced in protoporphyrin-containing red blood cell ghosts irradiated with approximately 400-nanometer light in the presence of oxygen. Incorporation of this cholesterol photooxidation product into normal red blood cells leads to increased osmotic fragility and eventual hemolysis. These results may be relevant to photohemolysis associated with erythropoietic protoporphyria.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Linoleic Acid Hydroperoxide: Impaired Bacterial Uptake by Alveolar Macrophages, a Mechanism of Oxidant Lung Injury.
A. Khandwala and J. B. L. Gee (1973)
Science 182, 1364-1365
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Reactions of Singlet Oxygen with Pine Pollen.
B. Dowty, J. L. Laseter, G. W. Griffin, I. R. Politzer, and C. H. Walkinshaw (1973)
Science 181, 669-670
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