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Science 9 March 1973:
Vol. 179. no. 4077, pp. 1011 - 1014
DOI: 10.1126/science.179.4077.1011
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Articles

Opiate Receptor: Demonstration in Nervous Tissue

Candace B. Pert 1 and Solomon H. Snyder 1

1 Departments of Pharmacology and Experimental Therapeutics and Psychiatry and the Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205

Tritiated naloxone, a powerful opiate antagonist, specifically binds to an opiate receptor of mammalian brain and guinea pig intestine. Competition for the opiate receptor by various opiates and their antagonists closely parallels their pharmacological potency. The opiate receptor is confined to nervous tissue.


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