Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 9 March 1973:
Vol. 179. no. 4077, pp. 1002 - 1003
DOI: 10.1126/science.179.4077.1002
Prev | Table of Contents | Next

Articles

Central Norepinephrine Metabolism in Affective Illness: MHPG in the Cerebrospinal Fluid

Robert M. Post 1, Edna K. Gordon 1, Frederick K. Goodwin 1, and William E. Bunney Jr. 1

1 Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, Maryland 20014

Concentrations of the norepinephrine metabolite 3-methoxy-4-hydroxyphenyl glycol in cerebrospinal fluid were measured by a gas chromatographic method in 34 patients with affective illness and in 44 controls. Concentrations of this metabolite in spinal fluid were significantly lower in depressed patients than in controls or manic patients. These low values may occur secondary to depressive phenomena such as reduced psychomotor activity, or they may reflect a primary change in norepinephrine metabolism in depressive illness.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Reduced Levels of Norepinephrine Transporters in the Locus Coeruleus in Major Depression.
V. Klimek, C. Stockmeier, J. Overholser, H. Y. Meltzer, S. Kalka, G. Dilley, and G. A. Ordway (1997)
J. Neurosci. 17, 8451-8458
   Abstract »    Full Text »    PDF »
Cerebrospinal Fluid Amine Metabolites: Relations`phips With Behavioral Measurements in Depressed, Manic, and Healthy Control Subjects.
D. E. Redmond Jr, M. M. Katz, J. W. Maas, A. Swann, R. Casper, and J. M. Davis (1986)
Arch Gen Psychiatry 43, 938-947
   Abstract »    PDF »
Cerebrospinal Fluid Monoamine and Monoamine Metabolite Levels and the Dexamethasone Suppression Test in Depression: Relationship to Life Events.
A. Roy, D. Pickar, M. Linnoila, A. R. Doran, and S. M. Paul (1986)
Arch Gen Psychiatry 43, 356-360
   Abstract »    PDF »
CSF and Urinary Biogenic Amines and Metabolites in Depression and Mania: A Controlled, Univariate Analysis.
S. H. Koslow, J. W. Maas, C. L. Bowden, J. M. Davis, I. Hanin, and J. Javaid (1983)
Arch Gen Psychiatry 40, 999-1010
   Abstract »    PDF »
Relation between plasma and cerebrospinal fluid levels of 3-methoxy-4-hydroxyphenylglycol.
I. Kopin, E. Gordon, D. Jimerson, and R. Polinsky (1983)
Science 219, 73-75
   Abstract »    PDF »
The Peripheral Kinetics of Norepinephrine in Depressive Illness.
M. Esler, J. Turbott, R. Schwarz, P. Leonard, A. Bobik, H. Skews, and G. Jackman (1982)
Arch Gen Psychiatry 39, 295-300
   Abstract »    PDF »
Memory impairment in Korsakoff's psychosis: a correlation with brain noradrenergic activity.
W. McEntee and R. Mair (1978)
Science 202, 905-907
   Abstract »    PDF »
Clinical and Biochemical Heterogeneity of Depressive Disorders.
J. W. MAAS (1978)
Ann Intern Med 88, 556-563
   Abstract »    PDF »
Probenecid-Induced Norepinephrine Elevations in Plasma and CSF.
C. R. Lake, J. H. Wood, M. G. Ziegler, M. H. Ebert, and I. J. Kopin (1978)
Arch Gen Psychiatry 35, 237-240
   Abstract »    PDF »
The Switch Process in Manic-Depressive Psychosis.
W. E. BUNNEY Jr., T. R. WEHR, J. C. GILLIN, R. M. POST, F. K. GOODWIN, and D. P. van KAMMEN (1977)
Ann Intern Med 87, 319-335
   Abstract »    PDF »
Effects of Sleep Deprivation on Mood and Central Amine Metabolism in Depressed Patients.
R. M. Post, J. Kotin, and F. K. Goodwin (1976)
Arch Gen Psychiatry 33, 627-632
   Abstract »    PDF »
Biogenic Amines and Depression: Biochemical and Pharmacological Separation of Two Types of Depression.
J. W. Maas and J. W. Maas (1975)
Arch Gen Psychiatry 32, 1357-1361
   Abstract »    PDF »
Cerebrospinal Fluid Amine Metabolites in Acute Schizophrenia.
R. M. Post, E. Fink, W. T. Carpenter Jr, and F. K. Goodwin (1975)
Arch Gen Psychiatry 32, 1063-1069
   Abstract »    PDF »
Antidepressant Response to Tricyclics and Urinary MHPG in Unipolar Patients: Clinical Response to Imipramine or Amitriptyline.
H. Beckmann and F. K. Goodwin (1975)
Arch Gen Psychiatry 32, 17-21
   Abstract »    PDF »
Inhibition of Dopamine-B-Hydroxylase in Manic Patients: A Clinical Trial With Fusaric Acid.
R. L. Sack and F. K. Goodwin (1974)
Arch Gen Psychiatry 31, 649-654
   Abstract »    PDF »
5-Hydroxyindoleacetic Acid in the Lumbar Fluid: A Specific Indicator of Spinal Cord Injury.
M. Bulat, Z. LackoviCacute, M. JakupCcaroneviCcaron, and I. Damjanov (1974)
Science 185, 527-528
   Abstract »    PDF »
Effects of Amitriptyline and Imipramine on Amine Metabolites in the Cerebrospinal Fluid of Depressed Patients.
R. M. Post and F. K. Goodwin (1974)
Arch Gen Psychiatry 30, 234-239
   Abstract »    PDF »
Depressive Disorders: Toward a Unified Hypothesis: Clinical, experimental, genetic, biochemical, and neurophysiological data are integrated.
H. S. Akiskal and W. T. McKinney Jr. (1973)
Science 182, 20-29
   Abstract »    PDF »
MHPG Excretion in Depressive Disorders: Relation to Clinical Subtypes and Desynchronized Sleep.
J. J. Schildkraut, B. A. Keeler, M. Papousek, and E. Hartmann (1973)
Science 181, 762-764
   Abstract »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)