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Science 2 March 1973:
Vol. 179. no. 4076, pp. 910 - 912
DOI: 10.1126/science.179.4076.910
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Articles

Diazacholesterol Myotonia: Accumulation of Desmosterol and Increased Adenosine Triphosphatase Activity of Sarcolemma

James B. Peter 1 and Walter Fiehn 1

1 Neuromuscular Disease Research Laboratories, Department of Medicine, University of California School of Medicine, Los Angeles 90024

Myotonia induced in rats by 20,25-diazacholesterol is accompanied by accumulation of desmosterol in serum, fragmented sarcoplasmic reticulum, and sarcolemma. Activities of (Na+,K+)- and Ca2+-stimulated adenosine triphosphatases of the sarcolemma are increased, but not the Mg2+-stimulated adenosine triphosphatase. The altered sterol composition of the sarcolemma may cause this type of myotonia by decreasing the chloride conductance of the membrane.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)