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Science 2 March 1973:
Vol. 179. no. 4076, pp. 906 - 907
DOI: 10.1126/science.179.4076.906
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Articles

Angiotensin II: Important Role in the Maintenance of Arterial Blood Pressure

J. Alan Johnson 1 and James O. Davis 1

1 Department of Physiology, University of Missouri School of Medicine, Columbia 65201

An angiotensin II antagonist, [1-sarcosine, 8-alanine]-angiotensin II, was given intravenously to anesthetized dogs with thoracic caval constriction and ascites to investigate the role of angiotensin II in the control of arterial pressure. The antagonist produced a striking fall in arterial pressure and in aldosterone secretion and an accompanying increase in plasma renin activity. In a control experiment, normal anesthetized dogs were given the angiotensin analog, but it failed to reduce arterial pressure or to influence plasma renin activity. In conscious dogs with caval constriction, the antagonist produced essentially the same drop in arterial pressure as observed in anesthetized animals. These results suggest an important role for angiotensin II in the maintenance of arterial pressure by its action on specific receptor sites in arteriolar smooth muscle and in the adrenal cortex.


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