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Science 2 March 1973:
Vol. 179. no. 4076, pp. 897 - 899
DOI: 10.1126/science.179.4076.897
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Articles

Amine Metabolites in Human Cerebrospinal Fluid: Effects of Cord Transection and Spinal Fluid Block

Robert M. Post 1, Frederick K. Goodwin 1, Edna Gordon 1, and Donald M. Watkin 2

1 Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, Maryland 20014
2 Veterans Administration Hospital, West Roxbury, Massachusetts 02132

Patients with spinal cord transection had normal concentrations of 5-hydroxyindoleacetic acid and low concentrations of 3-methoxy-4-hydroxyphenyl glycol in lumbar cerebrospinal fluid. The presence or absence of spinal fluid block in these patients did not affect concentrations of either amine metabolite. However, the concentration of homovanillic acid was lower in patients with spinal fluid block than in those without block. The results suggest that the spinal cord contributes to concentrations of 3-methoxy-4-hydroxyphenyl glycol and possibly 5-hydroxyindoleacetic acid, but contributes little to that of homovanillic acid in the lumbar spinal fluid of man.


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