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Science 23 February 1973:
Vol. 179. no. 4075, pp. 811 - 813
DOI: 10.1126/science.179.4075.811
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Articles

Graft versus Leukemia: Quantification of Adoptive Immunotherapy in Murine Leukemia

Mortimer M. Bortin 1, Alfred A. Rimm 1, and Edward C. Saltzstein 1

1 May and Sigmund Winter Research Laboratory, Mount Sinai Medical Center, Milwaukee, Wisconsin 53233, and Department of Medicine, Biostatistics, and Surgery, Medical College of Wisconsin, Milwaukee

Quantification of the antileukemic reactivity of transplanted immunocompetent cells from various allogeneic donors was achieved against a long-passage lymphocytic leukemia of AKR mice. Adoptive immunotherapy was the exclusive antileukemic treatment. Cells from DBA/2 donors exhibited maximal antileukemic effect, inactivating up to an estimated 107 leukemia cells. The cellular events were interpreted by using a theoretical cytokinetic construct.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
HLA Typing for Bone Marrow Transplantation: New Polymerase Chain Reaction--Based Methods.
A. B. Begovich and H. A. Erlich (1995)
JAMA 273, 586-591
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