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Science 16 February 1973:
Vol. 179. no. 4074, pp. 691 - 693
DOI: 10.1126/science.179.4074.691
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Articles

Association of the HL-A7 Cross-Reacting Group with a Specific Reaginic Antibody Response in Allergic Man

David G. Marsh 1, Wilma B. Bias 1, Susan H. Hsu 1, and Lawrence Goodfriend 2

1 Divisions of Clinical Immunology and Medical Genetics, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205
2 Division of Immunochemistry and Allergy, Royal Victorial Hospital, Montreal, Quebec, Canada

A relatively small proportion (17 percent) of individuals highly allergic to ragweed were found to develop marked reaginic (immunoglobulin E-mediated) skin sensitivity to a minor ragweed pollen allergen Ra5 (molecular weight 5200). Sensitivity to Ra5 was significantly associated with the possession of a major histocompatibility antigen of the HL-A7 cross-reacting group. This appears to be the first evidence of a strong association between a specific immune response and a specific group of closely related HL-A antigens in man.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Influenzal Vaccine Response in Systemic Lupus Erythematosus.
R. BRODMAN, R. GILFILLAN, D. GLASS, and P. H. SCHUR (1978)
Ann Intern Med 88, 735-740
   Abstract »    PDF »
Histocompatibility-2 System of Wild Mice IV. Ia and Ir Typing of Two Wild Mouse Populations.
J. Klein, C. F. Merryman, P. H. Maurer, M. Hauptfeld, and M. B. Gardner (1977)
Cold Spring Harb Symp Quant Biol 41, 457-463
   Abstract »    PDF »
HL-A linked antigen E immune response genes: an unproved hypothesis.
W. Bias and D. Marsh (1975)
Science 188, 375-377
   PDF »
IgE Levels in Atopic Dermatitis.
S. P. Stone, S. A. Muller, and G. J. Gleich (1973)
Arch Dermatol 108, 806-811
   Abstract »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)