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Science 16 February 1973:
Vol. 179. no. 4074, pp. 689 - 690
DOI: 10.1126/science.179.4074.689
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Articles

Myelination Inhibition Factor: Dissociation from Induction of Experimental Allergic Encephalomyelitis

Marian W. Kies 1, Bernard F. Driscoll 1, Fredrick J. Seil 2, and Ellsworth C. Alvord Jr. 3

1 Section on Myelin Chemistry, Laboratory of Cerebral Metabolism, National Institute of Mental Health, Bethesda, Maryland 20014
2 Department of Neurology, Stanford University School of Medicine, and Veterans Administration Hospital, Palo Alto, California 94304
3 Department of Pathology, University of Washington School of Medicine, Seattle 98195

Sensitization of guinea pigs with purified myelin basic protein induces experimental allergic encephalomyelitis (EAE) but does not induce a serum factor which inhibits myelin formation in vitro. This factor, induced by some unidentified constituent of whole central nervous system tissue, should not be characterized as a component of "EAE serum."


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