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Science 9 February 1973:
Vol. 179. no. 4073, pp. 580 - 582
DOI: 10.1126/science.179.4073.580
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Articles

A Hidden Antigenic Site Localized to the Constant Region of Light Chains of Immunoglobulins

Carla L. McLaughlin 1 and Alan Solomon 1

1 Memorial Research Center, University of Tennessee, Knoxville 37920

An antigenic site, which was not immunochemically demonstrable in the intact kgr light polypeptide chain, was exposed by enzymatic cleavage of the kgr chain into its variant half and constant half. This antigenic site located in the constant region the kgr chain was detected immunochemically by several antiserums that had specificity for this site. Treatment of an intact kgr chain with a dissociating agent resulted in the exposure of the hidden antigenic site, which was as readily detected in the unfolded polypeptide chain as in the isolated constant half.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)