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Science 2 February 1973:
Vol. 179. no. 4072, pp. 490 - 492
DOI: 10.1126/science.179.4072.490
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Articles

Lack of Tolerance to Dgr9-Tetrahydrocannabinol in Chimpanzees

Douglas P. Ferraro 1 and David M. Grilly 1

1 Department of Psychology, University of New Mexico, Albuquerque 87106

Five chimpanzees were given Dgr9-tetrahydrocannabinol (Dgr9THC): 1.0 milligram per kilogram of body weight for 21 days and 4.0 milligrams per kilogram of body weight for 42 days. Although accuracy and speed of performance on a delayed matching-to-sample task were significantly affected by both doses, tolerance to Dgr9THC did not develop. No long-term behavioral effects of Dgr9THC were observed after termination of the drug regimens.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
International Union of Pharmacology. XXVII. Classification of Cannabinoid Receptors.
A. C. Howlett, F. Barth, T. I. Bonner, G. Cabral, P. Casellas, W. A. Devane, C. C. Felder, M. Herkenham, K. Mackie, B. R. Martin, et al. (2002)
Pharmacol. Rev. 54, 161-202
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Science. ISSN 0036-8075 (print), 1095-9203 (online)