Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 2 February 1973:
Vol. 179. no. 4072, pp. 476 - 477
DOI: 10.1126/science.179.4072.476
Prev | Table of Contents | Next

Articles

2,3,7,8-Tetrachlorodibenzo-p-dioxin: A Potent Inducer of dgr-Aminolevulinic Acid Synthetase

Alan Poland 1 and Edward Glover 1

1 Department of Pharmacology and Toxicology, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642

2,3,7,8-Tetrachlorodibenzo-p-dioxin, a toxic contaminant frequently formed during the synthesis of the herbicide 2,4,5-trichlorophenoxyacetic acid, was shown to be a potent inducer of hepatic dgr-aminolevulinic acid synthetase in the chick embryo. As little as 4.66 x 10-12 mole of the contaminant per egg produces a significant increase in the activity of the enzyme. Induction of the enzyme is related to the dose of 2,3,7,8-tetrachlorodibenzo-p-dioxin and, in contrast to that produced with other drugs, is prolonged in time, with 70 percent of the maximum induced activity present 5 days after a single dose. This contaminant is implicated as the likely causative agent in an outbreak of porphyria cutanea tarda in workers in a factory where 2,4,5-trichlorophenoxyacetic acid was being synthesized.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
An Aryl Hydrocarbon Receptor Odyssey to the Shores of Toxicology: The Deichmann Lecture, International Congress of Toxicology-XI.
A. B. Okey (2007)
Toxicol. Sci. 98, 5-38
   Abstract »    Full Text »    PDF »
The molecular basis for differential dioxin sensitivity in birds: Role of the aryl hydrocarbon receptor.
S. I. Karchner, D. G. Franks, S. W. Kennedy, and M. E. Hahn (2006)
PNAS 103, 6252-6257
   Abstract »    Full Text »    PDF »
Clinical Laboratory Manifestations of Exposure to Dioxin in Children: A Six-Year Study of the Effects of an Environmental Disaster Near Seveso, Italy.
P. Mocarelli, A. Marocchi, P. Brambilla, P. Gerthoux, D. S. Young, and N. Mantel (1986)
JAMA 256, 2687-2695
   Abstract »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)