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Science 26 January 1973:
Vol. 179. no. 4071, pp. 402 - 405
DOI: 10.1126/science.179.4071.402
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Articles

Embryonic Chick Intestine in Organ Culture: Response to Vitamin D3 and Its Metabolites

R. A. Corradino 1

1 Department of Physical Biology, New York State Veterinary College, Cornell University, Ithaca 14850

Embryonic chick intestine maintained in organ culture responded to vitamin D3 and its metabolites 25-hydroxycholecalciferol and 1,25-dihydroxycholecalciferol by synthesis of calcium-binding protein and enchanced calcium-45 uptake. The dihydroxy metabolite was by far the most potent inducer of the protein and also acted more rapidly than vitamin D3 to stimulate isotope uptake. Despite its lower potency, vitamin D3 itself was effective.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
The Effects of Steroids Upon the Gastrointestinal Tract.
H. E. Black (1988)
Toxicol Pathol 16, 213-222
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Vitamin D Metabolism and Function.
H. F. DeLuca (1978)
Arch Intern Med 138, 836-847
   Abstract »    PDF »
Vitamin D: 3-deoxy-lalpha-hydroxyvitamin D3, biologically active analog of lalpha-dihydroxyvitamin D3.
A. Norman, M. Mitra, W. Okamura, and R. Wing (1975)
Science 188, 1013-1015
   Abstract »    PDF »


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