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Science 26 January 1973:
Vol. 179. no. 4071, pp. 393 - 395
DOI: 10.1126/science.179.4071.393
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Articles

Isolation of RNA Virus from Papillary Tumors of the Human Renal Pelvis

Arthur Y. Elliott 1, Elwin E. Fraley 1, Patrick Cleveland 1, Anthony E. Castro 1, and Nell Stein 1

1 Department of Surgery, Division of Urology, and Department of Microbiology, University of Minnesota Health Sciences Center, Minneapolis 55455

Virus particles were detected by electron microscopy in three papillary cancers of the human renal pelvis. Similar particles were seen in cells from all three tumors in primary culture. An RNA virus was isolated from these tumors. The serum of tumor patients contains neutralizing antibodies against virus isolated from two of the tumors. Initial studies suggest that this agent is not a known human RNA virus.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)