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Science 26 January 1973:
Vol. 179. no. 4071, pp. 391 - 393
DOI: 10.1126/science.179.4071.391
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Articles

Delta-9-Tetrahydrocannabinol: Localization in Body Fat

David S. Kreuz 1 and Julius Axelrod 1

1 Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, Maryland 20014

[14C]Dgr9-Tetrahydrocannabinol (Dgr9THC) was injected subcutaneously in rats every day for 1 to 26 days. Concentrations of Dgr9THC and its metabolites, 11-hydroxytetrahydrocannabinol and 8,11-dihydroxytetrahydrocannabinol, were determined in various tissues. After a single injection, the concentration of Dgr9THC in fat was ten times greater than in any other tissue examined, and persisted in this tissue for 2 weeks. With repeated injection, Dgr9THC and its metabolites accumulated in fat and brain.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Inhibition of Cellular Mediated Immunity in Marihuana Smokers.
G. G. Nahas, N. Suciu-Foca, J.-P. Armand, and A. Morishima (1974)
Science 183, 419-420
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