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Science 26 January 1973:
Vol. 179. no. 4071, pp. 384 - 386
DOI: 10.1126/science.179.4071.384
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Articles

Localization of Calcium Pump Activity in Smooth Muscle

Leon Hurwitz 1, David F. Fitzpatrick 1, Gamil Debbas 1, and Erwin J. Landon 1

1 Department of Pharmacology, Vanderbilt University Medical School, Nashville, Tennessee 37203

A microsomal fraction isolated from longitudinal smooth muscle of guinea pig ileum actively sequesters calcium ion in the presence of magnesium and adenosine triphosphate in a fashion previously described for microsomes of the rabbit aorta. This activity in guinea pig ileum appears to be associated primarily with the plasma membrane as is found in the red cell. By contrast the uptake of calcium in aortic smooth muscle appears to be associated to an appreciable extent with intracellular membranes, possibly analogous to the sarcoplasmic reticulum of skeletal muscle.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Protein Kinase Translocation as an Early Event in the Hormonal Control of Uterine Contraction.
S. G. Korenman, R. C. Bhalla, B. M. Sanborn, and R. H. Stevens (1974)
Science 183, 430-432
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Science. ISSN 0036-8075 (print), 1095-9203 (online)