Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.
American Society for Biochemistry and Molecular Biology

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 22 December 1972:
Vol. 178. no. 4067, pp. 1302 - 1304
DOI: 10.1126/science.178.4067.1302
Prev | Table of Contents | Next

Articles

Implantation of Exogenous Enzymatic Activity in Isolated Alveolar Macrophages

James Theodore 1, Julio C. Acevedo 1, and Eugene D. Robin 1

1 Departments of Medicine and Physiology, Stanford University School of Medicine, Stanford, California 94305

Alveolar macrophages acquired the capacity to oxidize uric acid after exposure to uricase. Presumably this resulted from intracellular incorporation of the enzyme by endocytosis. This approach may provide a general method for (i) testing regulatory biochemical mechanisms, (ii) therapeutic replacement of deficient regulatory macromolecules, and (iii) studying environmental factors that produce genetic alterations.

ADVERTISEMENT
Click Me!

ADVERTISEMENT
Click Me!

To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)