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Science 22 December 1972:
Vol. 178. no. 4067, pp. 1290 - 1292
DOI: 10.1126/science.178.4067.1290
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Articles

Evidence for Active Immunity to Morphine in Mice

Barry Berkowitz 1 and Sydney Spector 1

1 Pharmacology Section, Department of Physiological Chemistry, Roche Institute of Molecular Biology, Nutley, New Jersey 07110

The serum from mice actively immunized with a morphine immunogen contained antibodies that could bind dihydromorphine. Morphine effects were diminished in these "immunized" mice, and the concentration of morphine in their plasma was altered.


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