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Science 15 December 1972:
Vol. 178. no. 4066, pp. 1201 - 1203
DOI: 10.1126/science.178.4066.1201
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Articles

Ragweed Hay Fever: Genetic Control and Linkage to HL-A Haplotypes

Bernard B. Levine 1, Rishon H. Stember 1, and Marilena Fotino 2

1 Department of Medicine, New York University School of Medicine, New York 10016
2 Tissue Typing Laboratory, Division of Serology and Genetics, New York Blood Center, New York

Clinical ragweed pollenosis (hay fever) and IgE antibody production specific for antigen E (the major purified protein antigen from ragweed pollen extract) correlated closely with HL-A haplotypes in successive generations of seven families. HL-A associated IgE antibody responsiveness was antigen specific and extended also to IgE antibody production. These data indicate an immune response (Ir) gene specific for antigen E necessary but not sufficient for the development of hay fever. This appears to be the first documentation of an Ir gene in man.


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