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Science 24 November 1972:
Vol. 178. no. 4063, pp. 873 - 874
DOI: 10.1126/science.178.4063.873
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Articles

Hemoglobin Beta Chain Structural Variation in Mice: Evolutionary and Functional Implications

John G. Gilman 1

1 Laboratory of Genetics, University of Wisconsin, Madison 53706

The Hbbd allele at the hemoglobin beta chain locus of Mus musculus is composed of two linked genes, coding for structurally different beta chains, betadmin and betadmaj. Mus caroli has only one beta chain, which combines structural features of both betadmin and betadmaj and thus may be a Lepore type of beta chain. Sequence data suggest that selection may have been important in the evolution of the mouse beta chains.


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