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Science 24 November 1972:
Vol. 178. no. 4063, pp. 862 - 863
DOI: 10.1126/science.178.4063.862
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Articles

Location of the Second Gene Required for Expression of the Leukemia-Associated Mouse Antigen GIX

Elisabeth Stockert 1, Hidetoshi Sato 1, Katsuaki Itakura 1, Edward A. Boyse 1, Lloyd J. Old 1, and John J. Hutton 2

1 Division of Immunology, Sloan-Kettering Institute for Cancer Research, New York 10021
2 Division of Hematology, University of Kentucky Medical Center, Lexington 40506

Some mouse strains express GIX antigen on their thymocytes; others do not. Expression depends on two genes, Gv-1 and Gv-2, in linkage groups IX and I, respectively. Cells producing leukemia virus, however, express GIX antigen regardless of their inherited Gv-1 and Gv-2 genotype.


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