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Science 17 November 1972:
Vol. 178. no. 4062, pp. 757 - 759
DOI: 10.1126/science.178.4062.757
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Articles

Transfer Factor: Delayed Hypersensitivity to Schistosoma mansoni and Tuberculin in Macaca mulatta

Shirley E. Maddison 1, Martin D. Hicklin 1, Brian P. Conway 1, and Irving G. Kagan 1

1 Parasitology Section and Pathology Unit, Center for Disease Control, Health Services and Mental Health Administration, Atlanta, Georgia 30333

Delayed hypersensitivity in Macaca mulatta infected with either Schistosoma mansoni or mycobacteria was demonstrated by biopsies of skin test sites. Both dialyzable and nondialyzable leukocyte extracts from infected donors transferred delayed hypersensitivity to recipient monkeys. In two recipients, skin test conversion was associated with in vitro transformation of the recipients' lymphocytes.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)