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Science 10 November 1972:
Vol. 178. no. 4061, pp. 640 - 643
DOI: 10.1126/science.178.4061.640
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Articles

Hypothalamic Norepinephrine: Circadian Rhythms and the Control of Feeding Behavior

D. L. Margules 1, Michael J. Lewis 1, James A. Dragovich 1, and Adrienne S. Margules 1

1 Department of Psychology, Temple University, Philadelphia, Pennsylvania 19122

The time of day is a decisive determinant of the effects of l-norepinephrine on feeding behavior. During the dark, direct application of l-norepinephrine to the hypothalamus of rats suppressed feeding behavior. During the light, treatment with the same dose of l-norepinephrine facilitated feeding behavior. Thus, l-norepinephrine has dual and opposite effects on feeding behavior. A hypothalamic substrate that fluctuates in a circadian rhythm could account for both actions of l-norepinephrine.


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