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Science 10 November 1972:
Vol. 178. no. 4061, pp. 630 - 633
DOI: 10.1126/science.178.4061.630
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Articles

Proparathyroid Hormone: Biosynthesis by Human Parathyroid Adenomas

Joel F. Habener 1, Byron Kemper 2, John T. Potts Jr. 3, and Alexander Rich 4

1 Endocrine Unit, Massachusetts General Hospital, and Department of Medicine, Harvard Medical School, Boston 02114
2 Department of Biology, Massachusetts Institute of Technology, Cambridge 02139
3 Endocrine Unit, Massachusetts General Hospital, and Department of Medicine, Harvard Medical School
4 Department of Biology, Massachusetts Institute of Technology

Biosynthesis of a precursor (proparathyroid hormone) to human parathyroid hormone was demonstrated during incubation of tissue from parathyroid adenomas. The proparathyroid hormone is labeled more rapidly than parathyroid hormone during incubation with amino acids labeled with carbon-14 and is progressively converted to the hormone. Apparent differences in the relative rate of conversion of precursor to hormone found in different tumors suggest that proparathyroid hormone may accumulate in some of the tumors and be secreted into the circulation.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Hypercalcemia in Reticulum Cell Sarcoma Without Hyperparathyroidism or Skeletal Metastases.
F. R. SINGER, D. POWELL, C. MINKIN, J. E. BETHUNE, A. BRICKMAN, and J. W. COBURN (1973)
Ann Intern Med 78, 365-369
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Science. ISSN 0036-8075 (print), 1095-9203 (online)