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Science 10 November 1972:
Vol. 178. no. 4061, pp. 623 - 625
DOI: 10.1126/science.178.4061.623
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Articles

Hemoglobin Lepore Trait: Globin Synthesis in Bone Marrow and Peripheral Blood

Frances Gill 1, Jean Atwater 1, and Elias Schwartz 1

1 Cardeza Foundation for Hematologic Research and Department of Pediatrics, Jefferson Medical College, Philadelphia, Pennsylvania 19107

There was decreased synthesis of the beta-globin chain in the peripheral blood, and equal synthesis of agr- and non-agr-chains in the bone marrow of three patients with hemoglobin Lepore trait, similar to the findings in patients with heterozygous beta-thalassemia. There is a relative instability of the synthetic mechanism for normal beta-chain in these patients.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Hemoglobin Parchman: double crossover within a single human gene.
J. Adams 3rd, W. Morrison, and M. Steinberg (1982)
Science 218, 291-293
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Science. ISSN 0036-8075 (print), 1095-9203 (online)