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Science 10 November 1972:
Vol. 178. no. 4061, pp. 614 - 615
DOI: 10.1126/science.178.4061.614
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Articles

Molecular Structure of LSD

Roy W. Baker 1, Cyrus Chothia 1, Peter Pauling 1, and Hans Peter Weber 2

1 William Ramsay, Ralph Forster and Christopher Ingold Laboratories, University College London, London W.C.1, England
2 Pharmaceutical Division, Sandoz Ltd., Basle, Switzerland

The molecular configuration of lysergic acid diethylamide (LSD) in crystals of the iodobenzoate has been determined by using x-ray diffraction techniques. The configuration shows strain and steric hindrance and the conformation is fixed. Some of the implications of this for the hallucinogenic activity of LSD are discussed.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)