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Science 3 November 1972:
Vol. 178. no. 4060, pp. 513 - 514
DOI: 10.1126/science.178.4060.513
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Articles

Obesity: Evidence of Decreased Secretion of Glucagon

Jonathan K. Wise 1, Rosa Hendler 1, and Philip Felig 1

1 Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06510

The increase in concentration of glucagon in plasma caused by infusion of alanine was reduced in obese subjects as compared to that in nonobese control subjects. This was true when the subjects were in the postabsorptive state as well as after an 84-hour fast, at which time the basal glucagon concentration had risen in the nonobese subjects, but remained unaltered in the obese group.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Hyperinsulinemic Hypoglycemia Associated With a Neurofibrosarcoma.
S. S. Lyall, N. J. Marieb, J. K. Wise, J. L. Cornog, E. C. Neville, and P. Felig (1975)
Arch Intern Med 135, 865-867
   Abstract »    PDF »
Carbohydrate Homeostasis and Pancreatic Islet Cell Function in Thalassemia.
M. N. LASSMAN, M. GENEL, J. K. WISE, R. HENDLER, and P. FELIG (1974)
Ann Intern Med 80, 65-69
   Abstract »    PDF »


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