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Science 27 October 1972:
Vol. 178. no. 4059, pp. 417 - 418
DOI: 10.1126/science.178.4059.417
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Articles

Thyrotropin Releasing Hormone: Enhancement of Dopa Activity by a Hypothalamic Hormone

N. P. Plotnikoff 1, A. J. Prange Jr. 2, G. R. Breese 2, M. S. Anderson 3, and I. C. Wilson 4

1 Experimental Therapy Division, Abbott Laboratories, North Chicago, Illinois
2 Departments of Psychiatry and Pharmacology, University of North Carolina School of Medicine, Chapel Hill 27514
3 Experimental Therapy Division, Abbott Laboratories
4 Departments of Psychiatry and Pharmacology, University of North Carolina School of Medicine

Thyrotropin releasing hormone potentiates the behaviorial effects of dopa plus pargyline in mice. Because the potentiation occurs in hypophysectomized mice, as well as in normal mice, the phenomenon is independent of the release of thyroid stimulating hormone from the pituitary. Possible mechanisms and clinical implications are discussed.


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