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Science 27 October 1972:
Vol. 178. no. 4059, pp. 417 - 418
DOI: 10.1126/science.178.4059.417
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Articles

Thyrotropin Releasing Hormone: Enhancement of Dopa Activity by a Hypothalamic Hormone

N. P. Plotnikoff 1, A. J. Prange Jr. 2, G. R. Breese 2, M. S. Anderson 3, and I. C. Wilson 4

1 Experimental Therapy Division, Abbott Laboratories, North Chicago, Illinois
2 Departments of Psychiatry and Pharmacology, University of North Carolina School of Medicine, Chapel Hill 27514
3 Experimental Therapy Division, Abbott Laboratories
4 Departments of Psychiatry and Pharmacology, University of North Carolina School of Medicine

Thyrotropin releasing hormone potentiates the behaviorial effects of dopa plus pargyline in mice. Because the potentiation occurs in hypophysectomized mice, as well as in normal mice, the phenomenon is independent of the release of thyroid stimulating hormone from the pituitary. Possible mechanisms and clinical implications are discussed.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
The Thyrotropin-Releasing Hormone (TRH) Hypothesis of Homeostatic Regulation: Implications for TRH-Based Therapeutics.
K. A. Gary, K. A. Sevarino, G. G. Yarbrough, A. J. Prange Jr., and A. Winokur (2003)
J. Pharmacol. Exp. Ther. 305, 410-416
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Peptide-dopamine interactions in the central nervous system: implications for neuropsychiatric disorders.
A.J. Stoessl (1989)
J Psychopharmacol 3, 99-120
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Thyrotropin-releasing hormone: abundance in the skin of the frog, Rana pipiens.
I. Jackson and S Reichlin (1977)
Science 198, 414-415
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Thyrotropin releasing hormone: development of inactivation system during maturation of the rat.
J. Neary, J. Kieffer, P Federico, H Mover, F Maloof, and M Soodak (1976)
Science 193, 403-405
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Thyrotropin-Releasing Hormone: Regional Distribution in Rat Brain.
A. Winokur and R. D. Utiger (1974)
Science 185, 265-267
   Abstract »    PDF »
Thyrotropin-Releasing Hormone in Specific Nuclei of Rat Brain.
M. J. Brownstein, M. Palkovits, J. M. Saavedra, R. M. Bassiri, and R. D. Utiger (1974)
Science 185, 267-269
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Science. ISSN 0036-8075 (print), 1095-9203 (online)