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Science 27 October 1972:
Vol. 178. no. 4059, pp. 417 - 418
DOI: 10.1126/science.178.4059.417
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Articles

Thyrotropin Releasing Hormone: Enhancement of Dopa Activity by a Hypothalamic Hormone

N. P. Plotnikoff 1, A. J. Prange Jr. 2, G. R. Breese 2, M. S. Anderson 3, and I. C. Wilson 4

1 Experimental Therapy Division, Abbott Laboratories, North Chicago, Illinois
2 Departments of Psychiatry and Pharmacology, University of North Carolina School of Medicine, Chapel Hill 27514
3 Experimental Therapy Division, Abbott Laboratories
4 Departments of Psychiatry and Pharmacology, University of North Carolina School of Medicine

Thyrotropin releasing hormone potentiates the behaviorial effects of dopa plus pargyline in mice. Because the potentiation occurs in hypophysectomized mice, as well as in normal mice, the phenomenon is independent of the release of thyroid stimulating hormone from the pituitary. Possible mechanisms and clinical implications are discussed.


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Effects of Intrathecal Thyrotropin-Releasing Hormone (Protirelin) in Refractory Depressed Patients.
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Carbamazepine Increases Cerebrospinal Fluid Thyrotropin-Releasing Hormone Levels in Affectively Ill Patients.
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Peptide-dopamine interactions in the central nervous system: implications for neuropsychiatric disorders.
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Behavioral Effects of Protirelin in Schizophrenia.
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Thyrotropin-releasing hormone: abundance in the skin of the frog, Rana pipiens.
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Thyrotropin releasing hormone: development of inactivation system during maturation of the rat.
J. Neary, J. Kieffer, P Federico, H Mover, F Maloof, and M Soodak (1976)
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Regulation of the Hypophysiotropic Secretions of the Brain.
S. Reichlin (1975)
Arch Intern Med 135, 1350-1361
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Protirelin (TRH) in Depression.
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Thyrotropin-Releasing Hormone: Regional Distribution in Rat Brain.
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Thyrotropin-Releasing Hormone in Specific Nuclei of Rat Brain.
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Hypothalamic Releasing Factors and Parkinson Disease.
T. N. Chase, A. C. Woods, M. A. Lipton, and C. E. Morris (1974)
Arch Neurol 31, 55-56
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THR (Lopremone): Psychobiological Responses of Normal Women: I. Subjective Experiences.
I. C. Wilson, A. J. Prange Jr., P. P. Lara, L. B. Alltop, R. A. Stikeleather, and M. A. Lipton (1973)
Arch Gen Psychiatry 29, 15-21
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THR (Lopremone): Psychobiological Responses of Normal Women: II. Pituitary-Thyroid Responses.
A. J. Prange Jr., I. C. Wilson, P. P. Lara, J. F. Wilber, G. B. Breese, L. B. Alltop, and M. A. Lipton (1973)
Arch Gen Psychiatry 29, 28-32
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