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Science 20 October 1972:
Vol. 178. no. 4058, pp. 304 - 306
DOI: 10.1126/science.178.4058.304
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Articles

Cytotoxic Antibody in Normal Human Serums Reactive with Tumor Cells from Acute Lymphocytic Leukemia

Wilma B. Bias 1, George W. Santos 1, Philip J. Burke 1, Gordon M. Mullins 1, and Richard L. Humphrey 1

1 Divisions of Medical Genetics and Oncology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205

Serums showing complement-dependent cytotoxic reactions to acute lymphocytic leukemia cells were detected in three normal unimmunized subjects. These serums were reactive with tumor cells from 514 (514 tested) acute lymphocytic leukemia patients, and three (12 tested) patients with acute myelocytic leukemia; they did not react with tumor cells from patients with acute monocytic leukemia (two tested), with chronic lymphocytic leukemia (two tested) or with leukolymphosarcoma (two tested); nor did they react with normal lymphocytes from 52 different donors. These reactive serums appear to recognize antigens primarily associated with acute lymphocytic leukemia.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Cytophilic Antibodies in Man.
M. S. MITCHELL, M. B. MOKYR, G. T. ASPNES, and S. McINTOSH (1973)
Ann Intern Med 79, 333-339
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Science. ISSN 0036-8075 (print), 1095-9203 (online)