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Science 13 October 1972:
Vol. 178. no. 4057, pp. 164 - 166
DOI: 10.1126/science.178.4057.164
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Articles

Human Blood Monocytes: Stimulators of Granulocyte and Mononuclear Colony Formation in vitro

Paul A. Chervenick 1 and Albert F. LoBuglio 1

1 Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, and Department of Medicine, Ohio State School of Medicine, Columbus 43210

Human blood monocytes in a feeder layer or by use for conditioning medium produced a colony-stimulating factor capable of stimulating the in vitro growth of colonies of granulocytes and mononuclear cells from human and murine marrow. Lymphocytes and neutrophils did not stimulate colony formation, and medium conditioned by neutrophils was inhibitory. This suggests that the monocyte may control granulocyte proliferation and maturation.


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Science. ISSN 0036-8075 (print), 1095-9203 (online)