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Science 6 October 1972:
Vol. 178. no. 4056, pp. 75 - 77
DOI: 10.1126/science.178.4056.75
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Articles

6-Hydroxydopa Depletion of Brain Norepinephrine and the Facilitation of Aggressive Behavior

N. B. Thoa 1, B. Eichelman 1, J. S. Richardson 1, and D. Jacobowitz 1

1 Laboratories of Clinical Science and Behavioral Research, National Institute of Mental Health, Bethesda, Maryland

A significant increase in shock-induced aggression occurs in the rat 4 days after an intraventricular injection of 90 micrograms of 6-hydroxydopa. Both fluorescent histology and biochemical assay demonstrate that brain norepinephrine is reduced by 90 micrograms of 6-hydroxydopa, while brain dopamine remains unaltered. This suggests that one form of aggressive behavior (shock-induced aggression) is modulated through a central noradrenergic system.


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Science. ISSN 0036-8075 (print), 1095-9203 (online)