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Science 6 October 1972:
Vol. 178. no. 4056, pp. 58 - 60
DOI: 10.1126/science.178.4056.58
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Articles

Human-Mouse Cell Hybrids: A Suggestion of Structural Mutation for Dipeptidase-2 Deficiency in Mouse Cells

Thomas B. Shows 1, Joan May 1, and Linda Haley 1

1 Roswell Park Memorial Institute, Buffalo, New York 14203

The dipeptidase-2 enzyme is inactive in certain cultured cell lines from the mouse. In somatic cell hybrids between such deficient cells and diploid human fibroblasts, the mouse deficiency was complemented when the homologous human peptidase-A was retained. The results suggested that the murine peptidase deficiency was the result of a structural mutation, rather than a regulatory one.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)