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Science 6 October 1972:
Vol. 178. no. 4056, pp. 56 - 58
DOI: 10.1126/science.178.4056.56
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Articles

Evidence for the Neutral Hypothesis of Protein Polymorphism

Tsuneyuki Yamazaki 1 and Takeo Maruyama 1

1 National Institute of Genetics, Mishima, Shizuoka-ken, 411, Japan

Data for some 400 polymorphic proteins were examined with special reference to molecular evolution, by using a statistic that depends on neither mutation rate, population structure, nor other ecological factors. The result indicates that most of these polymorphisms are maintained in a population by mutation and random genetic drift.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Selectionism and Neutralism in Molecular Evolution.
M. Nei (2005)
Mol. Biol. Evol. 22, 2318-2342
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Amino Acid Difference Formula to Help Explain Protein Evolution.
R. Grantham (1974)
Science 185, 862-864
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Enzyme Polymorphism and Metabolism.
G. B. Johnson (1974)
Science 184, 28-37
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Evidence that Enzyme Polymorphisms Are Selectively Neutral, but Blood Group Polymorphisms Are Not.
T. Yamazaki and T. Maruyama (1974)
Science 183, 1091-1092
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Gene Pool of Higher Organisms as a Product of Evolution.
M. Kimura (1974)
Cold Spring Harb Symp Quant Biol 38, 515-524
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Science. ISSN 0036-8075 (print), 1095-9203 (online)