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Science 29 September 1972:
Vol. 177. no. 4055, pp. 1211 - 1214
DOI: 10.1126/science.177.4055.1211
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Articles
Deficits in Feeding Behavior after Intraventricular Injection of 6-Hydroxydopamine in Rats
Michael J. Ligmond 1 and
Edward M. Stricker 1
1 Psychobiology Programn, Depart, tnents of Biology and Psychology, University of Pittsburgh, Pittsburgh, Pennsylvania 15213
Intraventricular injections of 6-hydroxydopamine produced 95 percent depletion of telencephalic norepinephrine and 62 percent depletion of striatal dopamine in rats. Treated rats maintained body weight at subnormal levels and failed to increase food intake in response to a short-term decrease in glucose utilization. After treatment with the monoamine oxidase inhibitor pargyline, 6-hydroxydopamine produced no further norepinephrine depletion but increased the dopamnine depletion to 95 percent and produced complete aphagia. These effects are comparable to events that follow bilateral electrolytic lesions of the lateral hypothalanmus.
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