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Science 29 September 1972:
Vol. 177. no. 4055, pp. 1205 - 1207
DOI: 10.1126/science.177.4055.1205
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Articles

Human Prolactin: 24-Hour Pattern with Increased Release doring Sleep

J. F. Sassin 1, A. G. Frantz 2, E. D. Weitzman 3, and S. Kapen 3

1 Department of Neurology, Montefiore Hospital and Medical Center, and Albert Einstein College of Medicine, Bronx, New York 10467
2 Department of Medicinie, Columbia College of Physicians and Surgeons, and Presbyterian Hospital, New York 10032
3 Department of Neurology, Montefiore Hospital and Medical Center, and Albert Einstein College of Medicine

Human prolactin was measured in plasma by radioimmunoassay at 20 minute intervals for a 24-hour period in each of six normal adults, whose sleep-wake cycles were monitored polygraphically. A marked diurnal variation in plasma concentrations was demonstrated, with highest values during sleep; periods of episodic release occurred throughout the 24 hours.


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